With a pool of Gana, Garner, Onana and Iwobi to choose from, and Allan, Davies and Doucoure backing them up, I fail to see why we'd persist with a 2-man midfield.
In a 433 I think we'll usually see Garner or Onana as the 6, with Gana, Onana and Iwobi rotating through the two box-to-box berths...