Everton welcome Wigan to Goodison Park on Saturday, as The Latics see Chris Hutchings take charge for the first time.
Hutchings replaced Paul Jewell at the helm in pre-season, and after heavy spending in the transfer market this summer, the new boss will be looking to put an early dent in David Moyes' campaign.
Leighton Baines is to miss out for Everton against his former club with a hamstring injury, whilst fellow new-boy Steve Pienaar has received the necessary clearance to make his debut, after initial problems with his registration.
Tim Cahill's latest injury blow will rule him out of his side's opener after picking up a knock to his foot in pre-season, meanwhile Phil Jagielka is in line to make his Everton debut after signing from Sheffield United this summer.
Kilbane drafted in
Wigan will call upon Kevin Kilbane to fill the vacant left-back position, against his former club, as Hutchings searches for Baines' replacement.
Ryan Taylor is still ruled out with a shin injury, whilst summer signing Michael Brown is suspended for the clash and will miss his new side's first two Premier League games.
New skipper Mario Melchiot is set to make his debut, whilst fellow new-boys Jason Koumas, Antoine Sibierski and Titus Bramble are amongst those travelling to Everton.