Brighton's home Premier League match against Crystal Palace on Saturday, 17 September has been postponed because of a planned rail strike.
The Premier League says the fixture has been "regrettably" called off after receiving a request from Brighton.
The league added in a statement that industrial action on the rail network means there will be "no public transport available for supporters".
A new date for the game at Amex Stadium is yet to be announced.
Brighton chief executive Paul Barber said: "While we fully appreciate this will be of huge disappointment to both sets of fans, and causes disruption to both teams' fixture schedules as well as those of supporters, the safety of fans of both clubs, our matchday staff, players and officials must be the priority.
"We have taken into consideration how difficult it would be for fans of both clubs to attend the match without access to the rail network and we looked at a number of options and various contingency plans.
"This included additional travel options or moving the match to earlier or later in the same week, with Sunday afternoon the latest the fixture could be played on that weekend due to the international break.
"But it simply was not possible to play the match with a full capacity crowd in attendance."
@Alan Whittle
Are the PL taking the pi55 ?
Selhurst Park to the Amex Stadium is 46 miles so, allowing for a bit of traffic, about 90 minutes by car or coach - it's not like Palace were running a fleet of special trains.