TEAM NEWS
Long-term injury absentee Nemanja Vidic returns for Manchester United, but four other central defenders are unavailable for selection.
Rio Ferdinand injured his groin in training, joining Chris Smalling, Phil Jones and Jonny Evans on the sidelines.
Michael Carrick could deputise at the back while new £24m striker Robin van Persie is set to make his debut.
For Everton, midfielders Marouane Fellaini (groin strain) and Darron Gibson (thigh strain) are doubtful.
Vidic is set to return for the first time since sustaining knee ligament damage last December. It is not yet known how long Ferdinand will be out, but scan results are expected on Monday.
Smalling is expected to miss another six weeks after surgery on a broken metatarsal, while Jones is struggling to overcome repeated back spasms.
Evans had ankle surgery in May and returned to training earlier this month, but did not take any part in the club's pre-season matches.
MATCH PREVIEW
Robin van Persie's World Cup and European Championship goals
The eyes of the football world will be on Robin van Persie when he takes to the turf at Goodison Park. The left-footed Netherlands striker and former Arsenal captain's move from north London to Old Trafford surprised many - United have paid a substantial transfer fee for a 29-year-old, even if he was the Premier League's top goalscorer last season.
Another interesting narrative involves Wayne Rooney, who at the age of 26 is marking 10 years since making his top flight debut. The former Everton youngster played for the Toffees against Tottenham as a 16-year-old. He said at the weekend: "I still feel exactly the same about my football as I did when I made my debut. I'm still fairly young. I just hope I can play for another 10 years."
Plenty are backing Rooney and Van Persie to shine under Sir Alex Ferguson's stewardship, but Everton are expected to unveil their own potentially exciting striking partnership. Croatian forward Nikica Jelavic - who moved to Goodison Park on January transfer deadline day and scored 11 goals in 16 games - should link up well with former Rangers striking partner Steven Naismith. The 25-year-old joined as a free agent in July, having scored 28 goals in 98 league appearances while in Glasgow.
Failing to find the back of the net regularly enough has undermined Everton in recent seasons and 24-year-old Kevin Mirallas will add to the club's attacking options. Unfortunately for his new employer he signed too late to participate against United, but Everton boss David Moyes is backing his signing from Olympiakos: "He'll be a good addition to the squad, he's got a track record, he was an exceptional talent in Greece where he scored a lot of goals and was very exciting over there."
Moyes has lost the services of England international Jack Rodwell, who moved to Manchester City for £12m earlier in the month, as well as long-serving Tim Cahill. However, he is not short of options in midfield and re-signed Steven Pienaar from Tottenham to bolster his squad. The South African failed to settle in London following his move from Merseyside 18 months ago, and is a popular player in the blue half of the city.
The Toffees will also be determined not to suffer another one of their notoriously poor starts to the campaign. "Every year it is the same story with Everton," Pienaar has said. "The players tend to wake up in the second half of the season."
An Everton team out of the blocks quickly on Monday could pose a challenge to Manchester United but the visitors still start as favourites. However, United were also favourites when the two teams last met: Sunday 22 April and a 4-4 thriller that derailed the Red Devils' title chase. What price that scoreline again?