I'm English, but live in the US. I play, every season for the last 6 years. Its a heck of a lot more effort and work than English Fantasy Football. But it really fun.
I would be willing to set up a league for anyone on GOT who is interested, but I would not suggest anyone play unless:
1) They have a reasonable knowledge of the game - NO
2) They know how the game is played (its rules) - and I don't just mean basic - NO
3) Obviously its important to know the scoring system- NO
4) They know who the best 5 players are at each position (at least) - NO
5) They know who all the teams are, who has the best Quarterbacks, and who has the best defences - NO
6) Know what a QB, RB, RB, TE, K, and DEF are - NO
Seriously, anyone can play and I'd be willing to set it up, but its quite a complicated set of rules and scoring etc. The live draft is one of the best things about NFL Fantasy Football, but if people who have never played before, I would suggest an auto draft on this occasion.