The drunk thread
- Thread starter chicoazul
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Alio
They call me Avocado Baby
Good man, I know of the Tiger Beer. It's Grrrrrrrrrrrrrrrrrrrrreat
Phenom
Player Valuation: £70m
Good stuff tiger is.
TheFinnFan
Finners
just came to home from coaching juniors, first bite of koff....tshhh.....aaaaaaah
soon i have my own practise so i have to keep it together. after that i will get hammered. fridge full of aluminium
soon i have my own practise so i have to keep it together. after that i will get hammered. fridge full of aluminium
Clint Planet
Utter Cad.
I'm told I had a kebab last night. I really can't remember.
Titus Bramble
Best centre half to grace the Premier League
Bier Kellar up at the Union later, 2 1/2 pint steins filled up for £4 all night with the "German Stompers" getting everyone swaying. It's gonna be good!
Got bought a load of random beers for my Birthday off a friend
Just opened up one of these, Badger Golden Glory, with a hint of Peach
This is a nice one. Try fursty ferret if you like it
TheFinnFan
Finners
i dont usually drink wine but this is good.
Lambrusco Grasparossa di Castelvetro
Lambrusco Grasparossa di Castelvetro
Degs62
Player Valuation 10"
Got bought a load of random beers for my Birthday off a friend
Just opened up one of these, Badger Golden Glory, with a hint of Peach
Do badgers support the barcodes?
Red wine is making my head fuzzy
Hibbosculturedrightboot
Player Valuation: £15m
I discovered that eating ginger biscuits at 2am does not cure a Guinness hangover.
somuchfun
Player Valuation: £40m
Like Their Human Brethren, Seeking Solace in Alcohol
They were young males on the make, and they struck out not once, not twice, but a dozen times with a group of attractive females hovering nearby. So they did what so many men do after being repeatedly rejected: They got drunk, using alcohol as a balm for unfulfilled desire.
And not one flew off in search of a rotting banana.
Fruit flies apparently self-medicate just like humans do, drowning their sorrows or frustrations for some of the same reasons, scientists reported Thursday. Male flies subjected to what amounted to a long tease — in a glass tube, not a dance club — preferred food spiked with alcohol far more than male flies that were allowed to mate.
The study, posted online in the journal Science, suggests that some elements of the brain’s reward system have changed very little during evolution, and these include some of the mechanisms that support addiction. Levels of a brain chemical that is active in regulating appetite predicted the flies’ thirst for alcohol — and a similar chemical is linked to drinking in humans.
“Reading this study is like looking back in time, to see the very origins of the reward circuit that drives fundamental behaviors like sex, eating, and sleeping,†said Dr. Markus Heilig, the clinical director of the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse.
Dr. Heilig, who was not involved in the research, said that the findings also support new approaches to treating alcohol dependence. Researchers are investigating several compounds aimed at blunting alcohol urges.
Scientists have long known that other species have their methods of stress reduction. In lab studies, mice, rats, and monkeys drink more after periods of isolation, studies suggest; the same is true of mice that are bullied or are victims of aggression.
To test the relationship between stress and alcohol in fruit flies, researchers at the University of California, San Francisco, allowed one group of male flies to mate freely with available virgin females. Another group of male flies had the opposite experience: the females they mingled with had already mated, and were thus indifferent to any approach.
After four days, the flies in both groups fed in glass tubes outfitted with four straws, two providing a regular diet of yeast and sugar and the two containing yeast, sugar and 15 percent alcohol. Fruit flies as a rule will, like many humans, develop a taste for alcohol and in time a preference for the 15 percent solution. But the rejected flies drank a lot more on average, supping from the spiked mixture about 70 percent of the time, compared with about 50 percent for their sexually sated peers.
The researchers conducted several additional experiments to rule out other explanations. The flies were apparently using the alcohol as a way to compensate for their frustrated desire.
“It’s the first time we have shown this link between a social experience that involves reward and a drug-related behavior†in these flies, said Ulrike Heberlein, a neuroscientist at the University of California, San Francisco, and a co-author of the paper.
The other authors, all neuroscientists, are Galit Shohat-Ophir, Karla R. Kaun and Reza Azanchi; all four authors now also have appointments at the Howard Hughes Institute’s Janelia Farm Research Campus, in Ashburn, Va.
The researchers found that levels of a chemical active in the brain called neuropeptide F, or NPF, correlated strongly with the flies’ appetite for alcohol: when levels of NPF were low, alcohol consumption was high, and vice versa. The NPF molecule in flies is thought to be analogous to the action of chemical called neuropeptide Y in humans, or NPY.
Previous studies have found that NPY is involved in a wide range of behaviors, like eating, sleeping and response to stress. But the new study, and others, suggest that scientists could reduce drinking by developing drugs that enhance the activity of NPY, said George Koob, a professor of neurobiology and addiction at the Scripps Research Institute in La Jolla, Calif.
“The study implies that it is this system that goes haywire in addiction,†Dr. Koob said, “and that it’s very sensitive to stress. For instance, after you lose a loved one, or a relationship has crashed, you get dysphoric, your NPY goes down, and this provides a strong urge to drink a lot, whether you’re a mammal or a fruit fly.â€
They were young males on the make, and they struck out not once, not twice, but a dozen times with a group of attractive females hovering nearby. So they did what so many men do after being repeatedly rejected: They got drunk, using alcohol as a balm for unfulfilled desire.
And not one flew off in search of a rotting banana.
Fruit flies apparently self-medicate just like humans do, drowning their sorrows or frustrations for some of the same reasons, scientists reported Thursday. Male flies subjected to what amounted to a long tease — in a glass tube, not a dance club — preferred food spiked with alcohol far more than male flies that were allowed to mate.
The study, posted online in the journal Science, suggests that some elements of the brain’s reward system have changed very little during evolution, and these include some of the mechanisms that support addiction. Levels of a brain chemical that is active in regulating appetite predicted the flies’ thirst for alcohol — and a similar chemical is linked to drinking in humans.
“Reading this study is like looking back in time, to see the very origins of the reward circuit that drives fundamental behaviors like sex, eating, and sleeping,†said Dr. Markus Heilig, the clinical director of the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse.
Dr. Heilig, who was not involved in the research, said that the findings also support new approaches to treating alcohol dependence. Researchers are investigating several compounds aimed at blunting alcohol urges.
Scientists have long known that other species have their methods of stress reduction. In lab studies, mice, rats, and monkeys drink more after periods of isolation, studies suggest; the same is true of mice that are bullied or are victims of aggression.
To test the relationship between stress and alcohol in fruit flies, researchers at the University of California, San Francisco, allowed one group of male flies to mate freely with available virgin females. Another group of male flies had the opposite experience: the females they mingled with had already mated, and were thus indifferent to any approach.
After four days, the flies in both groups fed in glass tubes outfitted with four straws, two providing a regular diet of yeast and sugar and the two containing yeast, sugar and 15 percent alcohol. Fruit flies as a rule will, like many humans, develop a taste for alcohol and in time a preference for the 15 percent solution. But the rejected flies drank a lot more on average, supping from the spiked mixture about 70 percent of the time, compared with about 50 percent for their sexually sated peers.
The researchers conducted several additional experiments to rule out other explanations. The flies were apparently using the alcohol as a way to compensate for their frustrated desire.
“It’s the first time we have shown this link between a social experience that involves reward and a drug-related behavior†in these flies, said Ulrike Heberlein, a neuroscientist at the University of California, San Francisco, and a co-author of the paper.
The other authors, all neuroscientists, are Galit Shohat-Ophir, Karla R. Kaun and Reza Azanchi; all four authors now also have appointments at the Howard Hughes Institute’s Janelia Farm Research Campus, in Ashburn, Va.
The researchers found that levels of a chemical active in the brain called neuropeptide F, or NPF, correlated strongly with the flies’ appetite for alcohol: when levels of NPF were low, alcohol consumption was high, and vice versa. The NPF molecule in flies is thought to be analogous to the action of chemical called neuropeptide Y in humans, or NPY.
Previous studies have found that NPY is involved in a wide range of behaviors, like eating, sleeping and response to stress. But the new study, and others, suggest that scientists could reduce drinking by developing drugs that enhance the activity of NPY, said George Koob, a professor of neurobiology and addiction at the Scripps Research Institute in La Jolla, Calif.
“The study implies that it is this system that goes haywire in addiction,†Dr. Koob said, “and that it’s very sensitive to stress. For instance, after you lose a loved one, or a relationship has crashed, you get dysphoric, your NPY goes down, and this provides a strong urge to drink a lot, whether you’re a mammal or a fruit fly.â€
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