The advantage of Kane being out may come from the fact that Spurs essentially have 3 forward players Son, Llorente, and Moura, with Kane and Alli being injured. They’ll be going all out in mid week to win that CL tie and Pochettino has no good options on the bench to rotate them. They’ll then have to do this all again at the weekend whilst Guardiola can call on any combo of Aguero Jesus Sané Sterling Bernardo Silva or Mahrez.
Spurs are the big danger in the run in for City and if the league game was at White Hart Lane then alarm bells would be ringing but having it at the Etihad with Kane and Alli both potentially out is probably as beneficial as it gets if you had to play them at any point.