We aren't a top team, so it's about making us better than we already are, which playing with two strikers would help with IMO because it wouldn't leave our striker so isolated and would give him a partner to work with
I'd want 442 (Cue all the "You can't play 442 anymore" shouts) or at the very least an advanced 4411 with a second striker playing behind the key one up top
Heck, if we want to be nuts and go all out, 424 would probably work based on our attacking options (Richarlison and one of Bernard/Iwobi out wide whilst you put Kean and DCL in the middle of the front 4), although we'd ship LOTS of goals if we used it and we'd have to hope that we could score more than we concede (And against the genuine top teams it'd give them carte blanche to hammer us)