NEA about the PL, tbh.
But two losses (which they almost certainly would be without him purely down to how good his hold up play has been lately) is massive. As I've said, he got a nasty kick and I think it was more of a shock injury. His mobility for his goal was fine, it was just when he put pressure on his ankle that it flared up again.
Get him recovered tomorrow and I'd send him off to the sun for the weekend (same with Cleverley, Coleman and the other injured players). Get them back in fresh Monday and see where he is by Wednesday morning.
If there is any doubt he isn't fully fit, then don't risk him.